"This paper clearly shows that these FAD mutations cause a loss of presenilin function and gamma secretase activity, leading to the loss of neurons in the adult brain," says Shen. "The most important implication of our findings is that strategies that enhance rather than inhibit gamma secretase should be investigated as potential Alzheimer's therapies. They also may explain why a major clinical trial of a gamma secretase inhibitor failed to help patients and actually worsened their cognitive abilities." .
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