Showing posts with label immunosuppressant. Show all posts
Showing posts with label immunosuppressant. Show all posts

Drugs that suppress immune system may protect against Parkinson's: People who take immunosuppressants less likely to develop the disease -- ScienceDaily

Racette and colleagues analyzed Medicare Part D prescription drug
data on 48,295 people diagnosed with Parkinson's in 2009 and 52,324
people never diagnosed with Parkinson's. They identified 26 commonly
prescribed immunosuppressant drugs, representing six classes of
medications. The researchers determined which people in the data set had
been prescribed any of the drugs a year or more before the date of
diagnosis or by a pre-set cutoff date. Prescriptions written in the 12
months before diagnosis or by the cutoff were excluded to rule out any
chance that the prescriptions might have been linked to early signs of
the disease.
The researchers found that people taking drugs in either of two
classes were significantly less likely to develop Parkinson's than those
taking no immunosuppressants. People taking corticosteroids such as
prednisone were 20 percent less likely to be diagnosed with Parkinson's,
while those on inosine monophosphate dehydrogenase (IMDH) inhibitors
were about one-third less likely.

Here's the paper:-

Immunosuppressants and Risk of Parkinson Disease. Annals of Clinical and Translational Neurology, May 31, 2018

Type 1 Diabetes May Be Reversible With Immune Suppressor Protein

"A professor in Melbourne, Australia, who is on a mission to find a cure for type 1 diabetes, believes that the answer, or part of it, lies with an immune suppressor protein called CD52. And if it works for type 1 diabetes, then it may well work for other immune disorders, such as multiple sclerosis and rheumatoid arthritis, where disruption in the balance different kinds of T cell in the immune system causes it to attack the body's own healthy tissue."


Combination of two pharmaceuticals proves effective in the treatment of multiple sclerosis

The Cyclosporine and FK506 (tacrolimus)-series have been utilized in a chemically slightly altered form as immunosuppressant medications for a long time. Both suppress the cellular immune defenses. This effect is necessary in conjunction with organ transplants, but otherwise problematic for the organism. The specific combination of the two substances amplifies the protective effect on the nerve cells thanks to different but synergistic efficacy mechanisms. The impact on the immune defense is reduced at the same time, which results in fewer side effects

Read more at: http://medicalxpress.com/news/2012-11-combination-pharmaceuticals-effective-treatment-multiple.html#jCp

An immunosuppressive drug could delay the onset of neurodegenerative diseases

Rapamycin, a drug used to prevent rejection in transplants, could delay the onset of neurodegenerative diseases such as Alzheimer's and Parkinson's. This is the main conclusion of a study published in the Nature in which has collaborated the researcher Isidro Ferrer, head of the group of Neuropathology at the Bellvitge Biomedical Research Institute (IDIBELL) and the Bellvitge University Hospital and Full Professor of Pathological Anatomy at the University of Barcelona. The research was led by researchers from the International School for Advanced Studies (SISSA) in Trieste (Italy).

Read more at: http://medicalxpress.com/news/2012-10-immunosuppressive-drug-onset-neurodegenerative-diseases.html#jCp
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Presence of common infection—cytomegalovirus—helps to explain increased other virus susceptibility in aging adults

(Medical Xpress)—The first experimental proof that long-term infection with cytomegalovirus, or CMV, may impair the aging immune system's response to unrelated viruses – such as West Nile or the flu – has been published in the journal PLoS Pathogens.

Read more at: http://medicalxpress.com/news/2012-09-presence-common-infectioncytomegalovirushelps-virus-susceptibility.html#jCp

Immune drug (B cell killer) helps patients with serious kidney disorder

Rituximab, commonly used to treat immune disorders such as lymphoma and arthritis also benefits patients with an immune disorder of the kidneys that can lead to kidney failure, according to a study appearing in an upcoming issue of new study in the Journal of the American Society of Nephrology (JASN). The findings could help people who are living with the condition, called idiopathic membranous nephropathy (IMN), avoid taking the potentially toxic medications that are currently prescribed to treat it.
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Futurity.org – Immune suppressants relieve severe asthma

A type of severe asthma (asthmatic granulomatosis) improves when treated with drugs that suppress the immune system.