The Alzheimer's field has had its share of clinical trial flops.
Now there's a push to learn from past failures. Computational scientists
in pharmaceutical companies are guiding clinical trial design by first
putting drug candidates through their paces in simulations. Those are
proprietary, but C-Path’s Coalition Against Major Diseases has built
some open-access simulation tools…
Showing posts with label webinar. Show all posts
Showing posts with label webinar. Show all posts
Neurovascular Underpinnings of Alzheimer's Dementia | ALZFORUM WEBINAR
This will be on Wednesday, January 08, 2014 at 12:00 PM US EST
Communication between neurons in the human brain and the blood vessels that supply them is a busy two-way street. Arterioles and capillaries that feed the central nervous system respond to neuronal demands for nutrients and oxygen, while brain cells provide trophic support that keeps the blood vessels alive. Hurt one and the other suffers. How does this delicate balance fit with Alzheimer’s disease pathology? Historically, researchers have separated AD from vascular dementia. AD diagnostic criteria that the community followed for more than 20 years excluded anyone with vascular disease from the diagnosis (McKhann et al., 1984), while vascular dementia was considered primarily a disease of the blood vessels. Is it time to give up this dichotomy?
Can Network Analysis Identify Pathological Pathways in Alzheimer’s - AlzForum Alzheimer Research Live Discussions
: "In the April 25 Cell, Valur Emilsson at the Icelandic Heart Association and Eric Schadt at Icahn School of Medicine at Mount Sinai, New York, report that they have identified molecular networks that are perturbed in Alzheimer’s disease patients compared to normal, age-matched controls. Several of these networks comprise genes previously linked to AD, including TREM2 and CD33. The scientists also identified a new player, TYROBP, as a master regulator of these molecular modules. Meanwhile, in the April 25 Neuron, researchers led by Rudy Tanzi and Ana Griciuc at Massachusetts General Hospital, Charlestown, report that microglia in the AD brain overproduce CD33, which seems to prevent these cells from binding to and degrading amyloid-β. Together, these findings tighten the link between AD pathology and microglial dysfunction."
Unraveling the Secrets of the Epigenome:Webinar
"While the human genome continues to intrigue researchers with the complexities embedded in the entirety of its DNA sequence, what’s on DNA and how it's packaged are increasingly important for understanding disease, including cancer. This second webinar in The Scientist's Decoding DNA series will cover the Secrets of the Epigenome, discussing what is currently known about DNA methylation, histone modifications, and chromatin remodeling and how this knowledge can translate to useful therapies. Following brief presentations by our panel of experts, there will be a live Q&A session during which attendees can ask questions and discuss issues related to the burgeoning field of epigenetics.
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Unraveling the Secrets of the Epigenome: webinar
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| A section of DNA; the sequence of the plate-like units (nucleotides) in the center carries information. (Photo credit: Wikipedia) |
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Meet the Scientist Webinars - March, 2013 | Depression and Schizophrenia "Brain & Behavior Research Foundation (Formerly NARSAD)
Meet the Scientist Webinar Series hosted by Brain & Behavior Research Foundation Acting President and CEO, Jeffrey Borenstein, M.D. Hear leading mental health researchers present the latest in new technologies, diagnostic tools, early intervention strategies and next generation therapies for mental illness.
Uncovering the Meaning in Your NGS Data: Tackling the Biological Analysis and Interpretation of Sequence Variation | The Scientist Magazine®
Next generation sequencing has revealed a lot about genetic variations such as single nucleotide polymorphisms (SNPs), single nucleotide variations (SNVs), copy number variations (CNVs), insertions and deletions (indels), inversions and translocations. Information on genetic variations has been used to better understand the inheritance and susceptibility of certain diseases, response to drugs, signaling pathways involved in normal versus disease states and more. However, biological interpretation of thousands of variants is a bottleneck in extracting valuable insights from DNA sequencing studies, often requiring months of effort after completion of the reference genome alignment and variant calling steps. These limitations can largely be overcome by using more sophisticated informatics tools that can help interpret the biology accurately and in more detail.
The target audience for this webinar includes scientists in academia or industry in pharmaceutical drug discovery or biomarker research, CROs, laboratory technicians and managers as well as clinicians, who are using or looking to use NGS.
Live Chat: The Bugs Inside of Us - ScienceNOW
Our bodies, inside and out, are teeming with trillions of microbes. Most of them are our friends, helping us to digest food, strengthening our immune systems, and keeping dangerous enemy pathogens from invading our tissues and organs. Evidence is building that this resident community of microbes, called the microbiome, plays a major role in health and disease. Disorders as diverse as cancer, obesity, inflammatory bowel disease, psoriasis, asthma, and possibly even autism may be influenced by the microbiome when its normal composition is thrown off balance. How similar are the microbial communities of different people? How are scientists establishing links between microbes and health? And what might be done to alter the microbiome to prevent disease?
Join us for a live chat at 3 p.m. EDT on Thursday, 7 June, on this page. You can leave your questions in the comment box below before the chat starts. The full text of the chat will be archived on this page
Join us for a live chat at 3 p.m. EDT on Thursday, 7 June, on this page. You can leave your questions in the comment box below before the chat starts. The full text of the chat will be archived on this page
IMGENEX Webinar |Engineered Reporter Cell Lines for TLR, Innate Immunity, Inflammation and Immune Signaling
Image via Wikipedia
Harnessing the Power of Metagenomics: Applications, Methods, and Real World Examples
Image via WikipediaThe term metagenomics has been in the lexicon of life scientists for a number of years now. More recently this field has been showing rapid progress, particularly as DNA sequencing technology advances in leaps and bounds. The power of metagenomics has been clearly demonstrated in its application to many diverse areas—including characterizing the microbiomes of the human gut, seawater samples, and soil samples—impacting human health, ecology, and agriculture/agronomy. All microbes in a particular specimen can now be catalogued—and useful biomarkers identified—without the need for culturing of these organisms. This type of analysis also provides a truer representation of the in situ conditions present when sampling occurred. This live, video webinar will introduce the viewer to the important field of metagenomics and provide insight into how it can be integrated into their research.
Meet the Scientist: Treatments for Schizophrenia: Current Limitations and Future Strategies
A NARSAD webinar from Professor Jeffrey A. Lieberman, M.D.
Tuesday, June 21, 2011
Tuesday, June 21, 2011
Brain & Behavior Research Foundation - Meet the scientist webinars
Treatments for Schizophrenia: Current Limitations and Future Strategies: Jeffrey A. Lieberman,M.D.Columbia University
Development and Pharmacological Treatment of Schizophrenia Joseph T. Coyle, M.D.Harvard University
and others ............
as well as recordings of past webinars from NARSAD
Development and Pharmacological Treatment of Schizophrenia Joseph T. Coyle, M.D.Harvard University
and others ............
as well as recordings of past webinars from NARSAD
Meet the Scientist - How Do Genes Cause Mental Illness?
This is a NARSAD Webinar from Daniel Weinberger, whose research focuses on brain development and the role of genetics in mental illness.
Monday, May 23, 2011
Schizophrenia Research Forum: Online Discussions Neurexin—From Basic Biology to Cognitive Diseases
Schizophrenia Research Forum: Online Discussions
Global Metabolite Profiling: The Fast-Track for Functional GenomicsThe New York Academy of Sciences
A Webinar from the New York Academy of Sciences
On-Demand Webinars - Seahorse Bioscience
Free webinars in many interesting fields
Risk factors: Alzheimer's : Autism : Bipolar disorder : Childhood obesity: Chronic fatigue: Multiple sclerosis Parkinson's disease Schizophrenia
Kegg pathways Alzheimer's Parkinson's Schizophrenia Herpes simplex infection Cystic fibrosis CFTR interactome
Risk factors: Alzheimer's : Autism : Bipolar disorder : Childhood obesity: Chronic fatigue: Multiple sclerosis Parkinson's disease Schizophrenia
Kegg pathways Alzheimer's Parkinson's Schizophrenia Herpes simplex infection Cystic fibrosis CFTR interactome
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