Showing posts with label Allergen. Show all posts
Showing posts with label Allergen. Show all posts

NIH-supported researchers find link between allergen in red meat and heart disease | National Institutes of Health (NIH)

Only in recent years did scientists identify the main allergen in red
meat, called galactose-α-1,3-galactose, or alpha-Gal, a type of complex
sugar. They also found that a tick — the Lone Star tick — sensitizes
people to this allergen when it bites them. That is why red meat
allergies tend to be more common where these ticks are more prevalent,
such as the Southeastern United States, but also extending to other
areas, including Long Island, New York.


Researchers have suspected for some time that allergens can trigger
certain immunological changes that might be associated with plaque
buildup and artery blockages, but no one had identified a specific
substance that is responsible for this effect. In the current study,
researchers showed for the first time that a specific blood marker for
red meat allergy was associated with higher levels of arterial plaque,
or fatty deposits on the inner lining of the arteries. The blood marker
they identified is a type of antibody (immunoglobulin or IgE) that is
specific to the alpha-Gal allergen.

Air pollutants could boost potency of common airborne allergens -- ScienceDaily

A pair of air pollutants linked to climate change could also be major
contributors to the unparalleled rise in the number of people sneezing,
sniffling and wheezing during allergy season. The gases, nitrogen
dioxide and ground-level ozone, appear to provoke chemical changes in
certain airborne allergens that may increase their potency. That, in
combination with changes in global climate could help explain why
allergies are becoming more common.

SORTALLER:Predicting allergens based on Allergen Family

SORTALLER is an online allergen classifier based on allergen family featured peptide (AFFP) dataset and normalized BLAST E-values, which establish the featured vectors for support vector machine (SVM). AFFPs are allergen-specific peptides panned from irredundant allergens and harbor perfect information with noise fragments eliminated because of their similarity to non-allergens. SORTALLER performed significantly better than other existing software and reached a perfect balance with high specificity (98.4%) and sensitivity (98.6%) for discriminating allergenic proteins from several independent datasets of protein sequences of diverse sources, also highlighting with the Matthews correlation coefficient (MCC) as high as 0.970, fast running speed and rapidly predicting a batch of amino acid sequences with a single click.
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