Culprit hidden in plain sight in Alzheimer’s disease development: Combustion-derived nanoparticles in key brain target cells and organelles in young urbanites | Journal of Alzheimer's Disease

Culprit hidden in plain sight in Alzheimer’s disease development: Combustion-derived nanoparticles in key brain target cells and organelles in young urbanites | Journal of Alzheimer's Disease: "Missoula, MT, June 8, 2017 — A new study by researchers at the University of Montana, Universidad del Valle de México, Instituto Nacional de Pediatría, Boise State, and Universidad Nacional Autónoma de México, heightens concerns over the detrimental short- and long-term impact of airborne iron-rich strongly magnetic combustion-derived nanoparticles (CDNPs) present in young urbanites’ brains. Using transmission electron microscopy, the researchers documented by abundant combustion nanoparticles in neurons, glial cells, choroid plexus, and neurovascular units of Mexico City children, teens and young adults chronically exposed to concentrations above the US-EPA standards for fine particulate matter. Residents in Mexico City are exposed from conception to harmful neurotoxic air pollutants. These findings are published in the Journal of Alzheimer’s Disease."



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Exposure to nanoparticles may threaten heart health -- ScienceDaily

Nanoparticles, extremely tiny particles measured in billionths of a meter, are increasingly everywhere, and especially in biomedical products. Their toxicity has been researched in general terms, but now a team of Israeli scientists has for the first time found that exposure nanoparticles (NPs) of silicon dioxide (SiO2) can play a major role in the development of cardiovascular diseases when the NP cross tissue and cellular barriers and also find their way into the circulatory system. Their study, published in the December issue of Environmental Toxicology.

In this study, researchers exposed cultured laboratory mouse cells resembling the arterial wall cells to NPs of silicon dioxide and investigated the effects. SiO2 NPs are toxic to and have significant adverse effects on macrophages. a type of white blood cell that take up lipids, leading to atherosclerotic lesion development and its consequent cardiovascular events, such as heart attack or stroke. Macrophages accumulation in the arterial wall under atherogenic conditions such as high cholesterol, triglycerides, oxidative stress -- are converted into lipids, or laden "foam cells" which, in turn, accelerate atherosclerosis development.

Futurity.org – Are those tiny gold nanoparticles bad for you?

 "Pure gold nanoparticles found in everyday items such as personal care products can inhibit fat storage, slow wound healing, and accelerate wrinkling"

Immunoreactivity of Nanoparticles « Pharmaceutical Intelligence

As nanotechnology progresses from research and development to commercialization and use, it is likely that manufactured nanomaterials and nanoproducts will be released into the environment.

Adverse effects of nanoparticles on human health depend on individual factors such as genetics and existing disease, as well as exposure, and nanoparticle chemistry, size, shape, agglomeration state, and electromagnetic properties. Animal and human studies show that inhaled nanoparticles are lessefficiently removed than larger particles by the macrophage clearance mechanisms in the lung,causing lung damage, and that nanoparticles can translocate through the circulatory, lymphatic, and nervous systems to many tissues and organs, including the brain.

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