Tha authors uncovered a novel mechanism that allows proteins that direct pre-mRNA splicing -- RNA-binding proteins -- to induce a regulatory effect from greater distances than was thought possible," said first author Michael T. Lovci, of the Department of Cellular and Molecular Medicine, the Stem Cell Research Program and Institute for Genomic Medicine at UC San Diego.
Showing posts with label Human genome. Show all posts
Showing posts with label Human genome. Show all posts
PLOS Genetics: A Review of Bacteria-Animal Lateral Gene Transfer May Inform Our Understanding of Diseases like Cancer
Interesting conclusions:
Extensive lateral gene transfer (LGT) has been detected between bacteria and animals, particularly between endosymbionts and their hosts. Recent LGT may be associated specifically with endosymbionts that colonize germ cells and the germ stem cell of their respective hosts. The extensive LGT observed between Wolbachia endosymbionts and their invertebrate hosts suggests that LGT involving bacteria and animals may occur more frequently than was thought a decade ago. While vertebrates have an immune system and segregated gametes that may prevent transfers like those seen in invertebrates, transfers to the vertebrate somatic genome have not been appreciated and warrant further examination. Bacterial DNA integration may be a mutagen associated with noninherited genetic diseases, like cancer, as described in a recent paper demonstrating LGT from Acinetobacter spp. in leukemia samples and from Pseudomonas spp. in stomach cancer samples.
Viruses (other than retroviruses) also appear to have been integrated into animal genomes
See :-
Extensive lateral gene transfer (LGT) has been detected between bacteria and animals, particularly between endosymbionts and their hosts. Recent LGT may be associated specifically with endosymbionts that colonize germ cells and the germ stem cell of their respective hosts. The extensive LGT observed between Wolbachia endosymbionts and their invertebrate hosts suggests that LGT involving bacteria and animals may occur more frequently than was thought a decade ago. While vertebrates have an immune system and segregated gametes that may prevent transfers like those seen in invertebrates, transfers to the vertebrate somatic genome have not been appreciated and warrant further examination. Bacterial DNA integration may be a mutagen associated with noninherited genetic diseases, like cancer, as described in a recent paper demonstrating LGT from Acinetobacter spp. in leukemia samples and from Pseudomonas spp. in stomach cancer samples.
Viruses (other than retroviruses) also appear to have been integrated into animal genomes
See :-
Endogenous viral elements in animal genomes Katsourakis and Gifford, 2010
Scientists attacked over claim that 'junk DNA' is vital to life | Science | The Observer
Scientists on the Encode project – an international public consortium researching the human genome – argued that most of our DNA has a part to play.
But this idea is now the subject of an astonishingly vitriolic attack from other scientists, who say that Encode's "absurd" ideas are the work of people who know nothing about evolutionary biology. "News concerning the death of junk DNA has been greatly exaggerated," they insist.
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