Bacterial protein implicated in eating disorders - Medical News Today

Eating disorders (ED) such as anorexia nervosa, bulimia, and binge eating disorder affect approximately 5-10% of the general population, but the biological mechanisms involved are unknown.

Researchers at Inserm Unit 1073, "Nutrition, inflammation and dysfunction of the gut-brain axis" (Inserm/University of Rouen) have demonstrated the involvement of a protein produced by some intestinal bacteria that may be the source of these disorders. Antibodies produced by the body against this protein also react with the main satiety hormone, α-melanocyte-stimulating hormone, which is similar in structure. According to the researchers, it may ultimately be possible to correct this mechanism that causes variations in food intake.

These results are published in the journal Translational Psychiatry, in the online issue of 7 October 2014.
Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide α-MSH, at the origin of eating disorders

Preteen food choices may help predict eating disorders later

The study, presented recently at the International Conference on Eating Disorders in Austin, Texas, found the percentage of carbohydrates and fats girls ate at around the age of 11 helped to predict increasing dissatisfaction with the body by the age of 14. The researchers noted 15-year-old girls who ate little fat and a lot of carbohydrates were more likely to have erratic eating habits by age 19. This was particularly true for girls who were considered perfectionists.

Anorexia genes and KEGG Pathways

Anorexia genes lag far behind those of other disorders in terms of numbers: This KEGG pathway analysis povides some details of those so far identified. Dopamine, glutamate, GABA , neurotrophin and adipocytokine pathways figure most prominently.

Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse.

Anorexia risk factors

Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients.

Lactobacillus species are widely used as growth promoters in the farm industry and are linked to obesity in humans. The study of the bacterial flora in anorexic patients revealed an increase in Methanobrevibacter smithii a bacterium that  removes excess hydrogen and CO2 from the gut generating methane and contributing to  flatulence

Risk factors: Childhood obesity: Anorexia Tweet Add to Mendeley

Acute injection of ASP in the third ventricle inhibits food intake and locomotor activity in rats.

ASP  (complement component 3) decreases food intake, and stimulates triglyceride synthesis and glucose transport via interaction with its receptor C5L2 (GPR77). This is an anaphylatoxin receptor : The anaphylatoxins, complement components  C3a, C4a and C5a are generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis.The complement cascade is generally activated by pathogens.

Anorexia genes and risk factors
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New study sheds light on role of genetics in recovering from eating disorders

Anorexia genes and risk factors

Anorexia More Likely To Affect Those Born In Spring

Anorexia is more likely To affect those born in spring  suggesting an environmental influence
 
Risk factors in anorexia

In utero exposure to virus infections and the risk of developing anorexia nervosa.

The authors found that exposure in utero to chicken pox or rubella during the sixth month of pregnancy increased the risk of developing anorexia in girl children.



Risk factors: Anorexia

Anorexia nervosa gene and risk factor datasheet

Anorexia nervosa

Risk factors: Alzheimer's : Autism : Bipolar disorder : Childhood obesity: Chronic fatigue: Multiple sclerosis Parkinson's disease Schizophrenia  

Kegg pathways Alzheimer's Parkinson's Schizophrenia Herpes simplex infection Cystic fibrosis CFTR interactome 

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