Titers of herpes simplex virus type 1 antibodies positively correlate with grey matter volumes in Alzheimer's disease.

HSV-1 infection of the central nervous system targets the same brain
regions most affected in Alzheimer's disease (AD) and could play a
pathogenic role in AD. HSV-1 serum IgG titers were analyzed in patients
with mild AD (n = 83) and healthy controls (HC, n = 51); results were
correlated with cortical grey matter (GM) volumes as analyzed by MRI.
Seroprevalence and antibody (Ab) titers were comparable between AD and
HC; elevated Ab titers (>75th percentile) were nevertheless
significantly more frequent in AD and were positively correlated with
cortical bilateral temporal and orbitofrontal GM volumes.
HSV-1-specific-Ab could possibly play a protective role in the early
stages of AD.

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