We developed a protocol to inactivate Toxoplasma gondii (T. gondii)
tachyzoites employing 1 minute of ultraviolet (UV) exposure. We show
that this treatment completely inhibited parasite replication and cyst
formation in vitro and in vivo but did not affect the induction of a
robust IgG response in mice. We propose that our protocol can be used to
study the contribution of the humoral immune response to rodent
behavioral alterations following T. gondii infection.
tachyzoites employing 1 minute of ultraviolet (UV) exposure. We show
that this treatment completely inhibited parasite replication and cyst
formation in vitro and in vivo but did not affect the induction of a
robust IgG response in mice. We propose that our protocol can be used to
study the contribution of the humoral immune response to rodent
behavioral alterations following T. gondii infection.
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