Frontiers | HSV-1 and Alzheimer’s disease: more than a hypothesis | Experimental Pharmacology and Drug Discovery

Among the multiple factors concurring to Alzheimer’s disease (AD)
pathogenesis, greater attention should be devoted to the role played by
infectious agents. Growing epidemiological and experimental evidence
suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is
a risk factor for AD although the underlying molecular and functional
mechanisms have not been fully elucidated yet. Here, we review
literature suggesting the involvement of HSV-1 infection in AD also
briefly mentioning possible pharmacological implications of these
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