Some of the biological effects of sucralose described by Schiffman and Rother include:
alterations in insulin, blood glucose, and glucagon-like peptide 1 (GLP-1) levels,
alterations in insulin, blood glucose, and glucagon-like peptide 1 (GLP-1) levels,
- metabolism of sucralose in the gastrointestinal tract to metabolites whose identity and safety profile are unknown,
- induction of cyctochrome P450 and P-glycoprotein in the gastrointestinal
tract to levels that may limit the bioavailability of therapeutic
drugs, - reduction in the number and balance of beneficial bacteria in the gastrointestinal tract,
- histopathological findings in gastrointestinal tract including
lymphocytic infiltrates into epithelium, epithelial scarring, mild
depletion of goblet cells and glandular disorganization in the colon, - decomposition and generation of chloropropanols (a potentially toxic
class of compounds) during baking, and mutagenic alterations using
several types of biological assays
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