Brain cannabinoid CB(2) receptors modulate cocaine's actions in mice.

It was generally though that this subtype of cannabinoid receptor (CNR2) was specific to macrophages and not involved in CNS effects. Not any more. This form has also been genetically implicated in bipolar disorder Minocci  et al, 2011 and schizophrenia   Ishiguro et al, 2010
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