T cell mediated cerebral hemorrhages and microhemorrhages during passive Abeta immunization in APPPS1 transgenic mice.

Vaccination with beta-amyloid can lead to antigen and T cell induced cerebral microhemorrhages and acute hematomas, which are increased by T cell mediated activity.
This route is being actively pursued in Alzheimer's disease - despite meningoencephalitis and hemorrhages in treated patients. This no longer appears justifiable.
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