Alzheimer's disease gene signature says: beware of brain viral infections.

This is an important and interesting study, partitioning GWAS data, suggesting that several Alzheimer's disease susceptibility genes are related to viral defense.

As many AD genes are involved in the herpes simplex life cycle Ref and plaques appear to be repositories for herpes simplex binding proteins Ref  the evidence for viral involvement is rapidly gaining ground.

Regular viral screening in the ageing population and the use of available antivirals may be of clinical benefit.


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