Adult rats that had been exposed before birth and during nursing to a
mixture of chemicals (Phthalates) found in a wide range of consumer products have a
smaller medial prefrontal cortex (mPFC) and perform worse on an
attention-switching task than rats not exposed to the chemicals early in
life. These findings, published in JNeurosci, demonstrate a long-term influence of endocrine-disrupting compounds on brain development.
Daniel G. Kougias, Elli P. Sellinger, Jari Willing, Janice M. Juraska. Perinatal
exposure to an environmentally relevant mixture of phthalates results
in a lower number of neurons and synapses in the medial prefrontal
cortex and decreased cognitive flexibility in adult male and female rats. The Journal of Neuroscience, 2018; 0607-18 DOI: 10.1523/JNEUROSCI.0607-18.2018
mixture of chemicals (Phthalates) found in a wide range of consumer products have a
smaller medial prefrontal cortex (mPFC) and perform worse on an
attention-switching task than rats not exposed to the chemicals early in
life. These findings, published in JNeurosci, demonstrate a long-term influence of endocrine-disrupting compounds on brain development.
Daniel G. Kougias, Elli P. Sellinger, Jari Willing, Janice M. Juraska. Perinatal
exposure to an environmentally relevant mixture of phthalates results
in a lower number of neurons and synapses in the medial prefrontal
cortex and decreased cognitive flexibility in adult male and female rats. The Journal of Neuroscience, 2018; 0607-18 DOI: 10.1523/JNEUROSCI.0607-18.2018
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