In the first study of its kind, researchers from the New York-based
Human Microbiology Institute have discovered the role certain
bacteriophages may play in the onset of Parkinson's disease (PD). The
research is presented at ASM Microbe, the annual meeting of the American
Society for Microbiology, held from June 7th to June 11th in Atlanta,
Georgia.
The researchers, led by George, Tetz, M.D., Ph.D., Human Microbiology Institute, showed that the abundance of lytic Lactococcus phages was higher in PD patients when compared to healthy individuals.This abundance led to a 10-fold reduction in neurotransmitter-producing Lactococcus,
suggesting the possible role of phages in neurodegeneration.
Comparative analysis of the bacterial component also revealed
significant decreases in Streptococcus spp. and Lactobacillus spp. in PD.
Lactococcus are regulators of gut permeability and are
enteric dopamine producers, which plays a primary role in PD. "The
depletion of lactococcus due to high numbers of strictly lytic phages in
PD patients might be associated with PD development and directly linked
to dopamine decrease as well as the development of gastrointestinal
symptoms of PD," said Dr. Tetz.
Human Microbiology Institute have discovered the role certain
bacteriophages may play in the onset of Parkinson's disease (PD). The
research is presented at ASM Microbe, the annual meeting of the American
Society for Microbiology, held from June 7th to June 11th in Atlanta,
Georgia.
The researchers, led by George, Tetz, M.D., Ph.D., Human Microbiology Institute, showed that the abundance of lytic Lactococcus phages was higher in PD patients when compared to healthy individuals.This abundance led to a 10-fold reduction in neurotransmitter-producing Lactococcus,
suggesting the possible role of phages in neurodegeneration.
Comparative analysis of the bacterial component also revealed
significant decreases in Streptococcus spp. and Lactobacillus spp. in PD.
Lactococcus are regulators of gut permeability and are
enteric dopamine producers, which plays a primary role in PD. "The
depletion of lactococcus due to high numbers of strictly lytic phages in
PD patients might be associated with PD development and directly linked
to dopamine decrease as well as the development of gastrointestinal
symptoms of PD," said Dr. Tetz.
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