Schizophrenia and the Synapse | The Scientist Magazine®

Compared to the brains of healthy individuals, those of people with schizophrenia have higher expression of a gene called Complement C4, according to a paper published in Nature today (January 27). The gene encodes an immune protein that moonlights in the brain as an eradicator of unwanted neural connections (synapses). The findings, which suggest increased synaptic pruning is a feature of the disease, are a direct extension of genome-wide association studies (GWASs) that pointed to the major histocompatibility (MHC) locus as a key region associated with schizophrenia risk.
Post a Comment