Variants in Antiviral Genes are Risk Factors for Cognitive Decline and Dementia. - PubMed - NCBI

A gene association study of factors regulating antiviral response such
as interferon (IFN)-λ3, also known as IL-28B, mediator complex (Med) 23,
and interferon regulatory factor (IRF) 7 with cognitive deterioration
and Alzheimer's disease (AD) was performed. Differences in the TT
genotype distribution of IL-28B single nucleotide polymorphism (SNP)
between AD patients and controls were found. The GG genotype of Med23
gene appeared to influence the progression of the disease, being more
frequent in the APOE ε4 negative elderly that developed AD during the
five year follow-up. Leukocyte positivity for Epstein Barr virus (EBV) and human herpes virus
(HHV)-6 DNA was analyzed. Med23 GG genotype correlated with the
positivity to HHV-6 DNA. EBV and HHV-6 plasma IgG levels were also
investigated and EBV IgG levels were increased in AD with the IRF7 GG
genotype. A differential genetic background in genes regulating anti-virus
responses was associated with an increased risk of cognitive decline
and AD. EBV and HHV-6 appeared to be risk factors for AD in genetically
susceptible elderly.

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