Recently, the relationship between immunoreactivity to Epstein-Barr
virus (EBV) and hypo-vitamin D in multiple sclerosis (MS) patients has
been described. The aim of this study was to investigate whether vitamin
D3 supplementation in MS patients could influence the immune response
against latent EBV infection. Forty MS patients were recruited in this
study. Twenty-seven patients were supplemented with 50,000 IU/week of
vitamin D3 for 6 months and thirteen enrolled as controls.
25-Hydroxyvitamin D (25OHD) levels and IgG titers against EBNA1 and VCA
were determined pre- and post-supplementation. All the patients were
seropositive for EBV prior to vitamin D supplementation. In this cohort,
22.5% and 47.5% of the MS patients had deficient and insufficient
levels of 25OHD, respectively. Our findings confirm that antibody titers
against EBV in MS patients rise after the onset of the disease and
indicate that vitamin D3 supplementation could limit augmentation of
these titers in MS patients.
virus (EBV) and hypo-vitamin D in multiple sclerosis (MS) patients has
been described. The aim of this study was to investigate whether vitamin
D3 supplementation in MS patients could influence the immune response
against latent EBV infection. Forty MS patients were recruited in this
study. Twenty-seven patients were supplemented with 50,000 IU/week of
vitamin D3 for 6 months and thirteen enrolled as controls.
25-Hydroxyvitamin D (25OHD) levels and IgG titers against EBNA1 and VCA
were determined pre- and post-supplementation. All the patients were
seropositive for EBV prior to vitamin D supplementation. In this cohort,
22.5% and 47.5% of the MS patients had deficient and insufficient
levels of 25OHD, respectively. Our findings confirm that antibody titers
against EBV in MS patients rise after the onset of the disease and
indicate that vitamin D3 supplementation could limit augmentation of
these titers in MS patients.
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