A new Duke University study in mice suggests that in Alzheimer's disease, certain immune cells
that normally protect the brain begin to abnormally consume an
important nutrient: arginine. Blocking this process with a
small-molecule drug prevented the characteristic brain plaques and
memory loss in a mouse model of the disease.
Arginine deprivation and immune suppression in a mouse model of
Alzheimer's disease," Matthew J. Kan, Jennifer E. Lee, Joan G. Wilson,
Angela L. Everhart, Candice M. Brown, Andrew N. Hoofnagle, Marilyn
Jansen, Michael P. Vitek, Michael D. Gunn, Carol A. Colton. Journal of
Neuroscience, April 15, 2015. DOI: 10.1523/JNEUROSCI.4668-14.2015
that normally protect the brain begin to abnormally consume an
important nutrient: arginine. Blocking this process with a
small-molecule drug prevented the characteristic brain plaques and
memory loss in a mouse model of the disease.
Arginine deprivation and immune suppression in a mouse model of
Alzheimer's disease," Matthew J. Kan, Jennifer E. Lee, Joan G. Wilson,
Angela L. Everhart, Candice M. Brown, Andrew N. Hoofnagle, Marilyn
Jansen, Michael P. Vitek, Michael D. Gunn, Carol A. Colton. Journal of
Neuroscience, April 15, 2015. DOI: 10.1523/JNEUROSCI.4668-14.2015
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