Immune gene variant magnifies Parkinson's risk from insecticide exposure

The findings implicate a type of pesticide called pyrethroids, which
are found in the majority of commercial household insecticides, and are
being used more in agriculture as other insecticides are being phased
out. Although pyrethroids are neurotoxic for insects, exposure to them is generally considered safe for humans by federal authorities.
The study is the first making the connection between pyrethroid
exposure and genetic risk for Parkinson's, and thus needs follow-up
investigation, says co-senior author Malu Tansey, PhD, associate
professor of physiology at Emory University School of Medicine.
The genetic variation the team probed, which has been previously tied
to Parkinson's in larger genome-wide association studies, was in a
non-coding region of a MHC II (major histocompatibility complex class
II) gene, part of a group of genes that regulate the immune system.

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