OBJECTIVES:The potential influence of infections andimmunological changes on the aetiology and pathogenesis of bipolar disorder (BD) has been discussed. Our aim was to detect intrathecal specific antibody synthesis against the neurotropic infectious agents that have previously been linked to BD.
METHODS:Paired cerebrospinal fluid (CSF) and serum samples from 40 patients with BD
were analysed using the enzyme-linked immunosorbent assay to detect the
concentration of antibodies against the following neurotropic infectious
pathogens: Toxoplasma gondii (T. gondii), herpes simplex virus (HSV)
types 1 and 2, cytomegalovirus (CMV), and Epstein-Barr virus (EBV). The
specific antibody index (AI) was calculated, and an AI > 1.4 was
considered to be evidence of intrathecal specific antibody synthesis.
Twenty-six patients with pseudotumour cerebri served as controls.