Popular artificial sweetener, Sucralose, not so sweet

The study involved an experiment using Sprague-Dawley rats that were
administered the artificial sweetener over a 12-week period. Following a
bacterial analysis of the rats' fecal samples and measurement of fecal
pH, the article concluded that artificial sweetener resulted in various
adverse effects in the rats, including:

  • Reduction in beneficial fecal microflora
  • Increased fecal pH
  • Enhanced expression levels of P-gp, CYP3A4,and CYP2D1, which are known to limit the bioavailability of orally administered drugs
"At concentrations typically used in foods and drinks, sucralose suppresses beneficial bacteria
in the gastrointestinal tract with less effect on pathogenic bacteria,"
article co-author Susan Schiffman, Ph.D said. "Most consumers are
unaware of these effects because no warning label appears on products
containing sucralose." Schiffman also said went onto saythat the change
in balance of gastrointestinal bacteria has been associated with weight
gain and obesity. At elevated levels, sucralose also damages DNA.
These biological effects occur at the levels of sucralose currently
approved by regulatory agencies for use in the food supply.

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