BACKGROUND AND PURPOSE:Previous studies suggested that the overall burden of prior infections contributes to cardiovascular
diseases and stroke. In the present study, the association between
infectious burden (IB) and Alzheimer's disease (AD) was examined.
METHODS:Antibody titers to common infectious pathogens including cytomegalovirus (CMV),
herpes simplex virus type 1 (HSV-1), Borrelia burgdorferi, Chlamydophila
pneumoniae and Helicobacter pylori were measured by enzyme-linked
immunosorbent assay in 128 AD patients and 135 healthy controls. IB was
defined as a composite serological measure of exposure to these common