Research presented by Dr. Lynn Raymond, from the University of British
Columbia, shows that blocking a specific class of glutamate receptors,
called extrasynaptic NMDA receptors, (with memantine )can improve motor learning and
coordination, and prevent cell death in animal models of Huntington
disease. As Huntington disease is an inherited condition that can be
detected decades before any clinical symptoms are seen in humans, a
better understanding of the earliest changes in brain cell (neuronal)
function, and the molecular pathways underlying those changes, could
lead to preventive treatments that delay the onset of symptoms and
neurodegeneration.
Columbia, shows that blocking a specific class of glutamate receptors,
called extrasynaptic NMDA receptors, (with memantine )can improve motor learning and
coordination, and prevent cell death in animal models of Huntington
disease. As Huntington disease is an inherited condition that can be
detected decades before any clinical symptoms are seen in humans, a
better understanding of the earliest changes in brain cell (neuronal)
function, and the molecular pathways underlying those changes, could
lead to preventive treatments that delay the onset of symptoms and
neurodegeneration.
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