Characterization of salivary proteins of schizophrenic and bipolar disorder patients by top-down proteomics.

The analysis of whole saliva of 32 subjects with diagnosis of
schizophrenia (SZ), 17 with diagnosis of bipolar disorder (BD), and 31
healthy subjects divided in non smokers (HN; n=19) and smokers (HS;
n=12) using an HPLC-ESI-MS top-down platform is reported in this study.
Both SZ and BD revealed more than 10 fold mean increase of α-defensins
1-4, S100A12, cystatin A and S-derivatives of cystatin B levels with
respect to the HN and HS control groups. No differences of protein
levels were observed between SZ and BD groups and between HN and HS
groups. Moreover, the correlations coefficients among the different
proteins were significantly better in BD group than in SZ group.


study on whole saliva confirms a shizophrenia-associated dysregulation
of immune pathway of peripheral white blood cells and suggests that the
dysregulation of BD group could involve the activation of more specific
cell type than those of SZ group.

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