Epstein-Barr virus and Mycobacterium avium subsp. paratuberculosis (MAP)
have been associated to multiple sclerosis (MS). We searched for
antibodies against the homologous peptides Epstein-Barr virus nuclear
antigen 1 (EBNA1)400-413, MAP_0106c protein (MAP)121-132, and myelin basic protein (MBP)85-98
on a MS Sardinian cohort, showing that these antibodies are highly
prevalent among MS patients compared to healthy controls. Competitive
assay demonstrated that antibodies recognizing EBNA1400-413 and MAP121-132 cross-react with MBP85-98,
possibly through a molecular mimicry mechanism. Indeed, the fact that
peptides from different pathogens can be cross-recognized by antibodies
targeting self-epitopes supports the hypothesis that EBV and MAP might
trigger autoimmunity through a common target.
have been associated to multiple sclerosis (MS). We searched for
antibodies against the homologous peptides Epstein-Barr virus nuclear
antigen 1 (EBNA1)400-413, MAP_0106c protein (MAP)121-132, and myelin basic protein (MBP)85-98
on a MS Sardinian cohort, showing that these antibodies are highly
prevalent among MS patients compared to healthy controls. Competitive
assay demonstrated that antibodies recognizing EBNA1400-413 and MAP121-132 cross-react with MBP85-98,
possibly through a molecular mimicry mechanism. Indeed, the fact that
peptides from different pathogens can be cross-recognized by antibodies
targeting self-epitopes supports the hypothesis that EBV and MAP might
trigger autoimmunity through a common target.
No comments:
Post a Comment