A step closer to understanding how BPA may promote breast cancer growth - Medical News Today

Subhrangsu Mandal, associate professor of chemistry/biochemistry, and
Arunoday Bhan, a PhD student in Mandal's lab, looked at a molecule
called RNA HOTAIR. HOTAIR is an abbreviation for long, non-coding RNA, a
part of DNA in humans and other vertebrates. HOTAIR does not produce a
protein on its own but, when it is being expressed or functioning, it
can suppress genes that would normally slow tumor growth or cause cancer cell death.
High levels of HOTAIR expression have been linked to breast tumors, pancreatic and colorectal cancers, sarcoma and others.
UT Arlington researchers found that when breast cancer
and mammary gland cells were exposed to BPA in lab tests, the BPA
worked together with naturally present molecules, including estrogen, to
create abnormal amounts of HOTAIR expression. Their results were
published online recently by the Journal of Steroid Biochemistry and Molecular Biology

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