According to Block, her team's work shows that many components of
urban air pollution, including the particle components of air pollution,
also called particulate matter, and gases, such as ground level ozone,
activate microglia.
Some of the problems with this cell type come in when the same
molecular tools used by microglia internalize (eat) and clean up toxic
stimuli and accidentally trigger the switch to an excessive, angry
activation state. The work she presented reveals how air pollution does
this, essentially leaving microglia with much more than a mouthful. Her
lab has discovered that the MAC1 pattern recognition receptor may be a
common mechanism through which microglia detect and ultimately
misinterpret different forms of air pollutionas an invading pathogen to result in excessive production of reactive oxygen species and consequent damage to neighboring brain cells.
Further, ongoing research in Block's lab aims to define where damage
to the lungs through inhaled toxicants produces injury signals in the
circulation that are not only detected by microglia in the brain, but
are responsible for shifting microglia to a deleterious phenotype
impacting central nervous system health. She refers to this as a
"Lung-Brain Axis."
urban air pollution, including the particle components of air pollution,
also called particulate matter, and gases, such as ground level ozone,
activate microglia.
Some of the problems with this cell type come in when the same
molecular tools used by microglia internalize (eat) and clean up toxic
stimuli and accidentally trigger the switch to an excessive, angry
activation state. The work she presented reveals how air pollution does
this, essentially leaving microglia with much more than a mouthful. Her
lab has discovered that the MAC1 pattern recognition receptor may be a
common mechanism through which microglia detect and ultimately
misinterpret different forms of air pollutionas an invading pathogen to result in excessive production of reactive oxygen species and consequent damage to neighboring brain cells.
Further, ongoing research in Block's lab aims to define where damage
to the lungs through inhaled toxicants produces injury signals in the
circulation that are not only detected by microglia in the brain, but
are responsible for shifting microglia to a deleterious phenotype
impacting central nervous system health. She refers to this as a
"Lung-Brain Axis."
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