The rare duplication in PAK7 increases the risks of developing schizophrenia or bipolar disorder more than 10-fold.According to the authors, the PAK7 gene family promotes growth and maintenance of brain connections in a pathway that is regulated by a previously known risk gene, called DISC1.
Both DISC1 and PAK7 interact with each other at the synapse level, the researchers say, which suggests that PAK signaling helps maintain synaptic networks - a mechanism that may play a role in development of schizophrenia and bipolar disorder.
Both DISC1 and PAK7 interact with each other at the synapse level, the researchers say, which suggests that PAK signaling helps maintain synaptic networks - a mechanism that may play a role in development of schizophrenia and bipolar disorder.
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