George Bloom, Ph.D., and colleagues at the University of Virginia (UVA) have pursued the hypothesis: that interactions between tau and beta-amyloid drive adult neurons into the forbidden pathway of "cell cycle re-entry" (CCR).
Dr. Bloom will present additional evidence supporting the role of CCR in AD on Sunday, Dec. 15, at the American Society for Cell Biology (ASCB) annual meeting in New Orleans. He will report the identification of a critical balance point between tau and a master cellular regulator that amyloid-beta oligomers disrupt.
A novel group of proteins, Rac1, Gαs (Gs alpha) and NCAM, and two protein kinase complexes, mTORC1 and mTORC2, play a role in driving mature neurons to their death, according to the UVA researchers.
Dr. Bloom will present additional evidence supporting the role of CCR in AD on Sunday, Dec. 15, at the American Society for Cell Biology (ASCB) annual meeting in New Orleans. He will report the identification of a critical balance point between tau and a master cellular regulator that amyloid-beta oligomers disrupt.
A novel group of proteins, Rac1, Gαs (Gs alpha) and NCAM, and two protein kinase complexes, mTORC1 and mTORC2, play a role in driving mature neurons to their death, according to the UVA researchers.
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