A new study confirms that many cognitively normal older adults harbor neurodegenerative changes akin to Alzheimer's disease (AD), but without amyloid-β (Aβ) deposits.
These changes are associated with cerebrovascular disease and cognitive performance, which suggests that neurodegenerative pathology can emerge through non-Aβ pathways within regions most affected by AD, say Miranka Wirth, PhD, from the Helen Wills Neuroscience Institute, University of California, Berkeley, and colleagues.
Their study was published online October 28 in JAMA Neurology.
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