The team collaborated in a series of studies performed in human post-mortem brain tissue. Working with Professor Coleman and Dr Diego Mastroeni at the Banner Sun Health Research Institute (Sun City, AZ, US), the researchers found that AD pathology in humans was associated with different methylation and hydroxymethylation patterns in the hippocampus compared with those seen in normal ageing.
"We have found robust decrements of 5-mC and 5-hmC in the hippocampus of AD patients when compared to carefully-matched controls. Interestingly, this decrease correlated with hippocampal amyloid plaque load," explained Dr van den Hove.
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