Hypothalamic inflammation may drive body ageing .

Brain Is Command Center for Aging | The Scientist Magazine®: "Inflammation in the hypothalamus may underlie aging of the entire body, according to a study published today (May 1) in Nature. Over-activation of the inflammatory protein nuclear factor kB (NF-κB) in the brain region leads to a number of aging-related changes in mice, from cognitive decline to muscle weakness. Unexpectedly, this process promotes aging at least in part by suppressing gonadotropin-releasing hormone (GnRH), which stimulates adult neurogenesis."

Nature Paper:

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

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