Trypanosome Lytic Factor (TLF) has emerged as an arm of innate immunity, present only in humans and select non-human primates. TLF was originally discovered in human blood as a minor form of High-density lipoprotein (HDL), (good cholesterol), that kills the African trypanosome, Trypanosoma brucei, making humans resistant to infection. Participants will discuss this finding as well as how understanding these mechanism will provide insights as to other pathogens that TLF should kill, as well as offer potential avenues to therapeutically augment or mimic TLF action. TLF is a mixture of apolipoproteins APOL1 /igm APOA1 and haptoglobin-related protein
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