Medscape Today: (Registration required) In the current study, the researchers used data from 2 population-based registers, the Danish Psychiatric Central Register and the Danish National Hospital Register, and selected all individuals born in Denmark between 1981 and 2000, which totalled 843,390 individuals.
They then identified 3409 individuals who had a first hospital contact with schizophrenia from 1991 through 2010. Of these, 1549 were exposed to an infection during their childhood that required hospitalization.
The study showed that individuals who were hospitalized for infection during childhood were almost 50% more likely to develop schizophrenia than individuals who were not, with a relative risk (RR) of 1.45 (95% confidence interval [CI], 1.35 - 1.55).
"This higher risk held if they were hospitalized for an infection at any given age before the onset of schizophrenia," Nielsen said.
Bacterial infection was associated with the highest risk (RR, 1.73; 95% CI, 1.55 - 1.92). If the liver was infected, that relative risk increased to 4.05 (95% CI, 1.45 - 8.71), Nielsen reported.
Viral infections increased the risk by 40% (RR, 1.40; 95% CI, 1.25 - 1.56)."
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They then identified 3409 individuals who had a first hospital contact with schizophrenia from 1991 through 2010. Of these, 1549 were exposed to an infection during their childhood that required hospitalization.
The study showed that individuals who were hospitalized for infection during childhood were almost 50% more likely to develop schizophrenia than individuals who were not, with a relative risk (RR) of 1.45 (95% confidence interval [CI], 1.35 - 1.55).
"This higher risk held if they were hospitalized for an infection at any given age before the onset of schizophrenia," Nielsen said.
Bacterial infection was associated with the highest risk (RR, 1.73; 95% CI, 1.55 - 1.92). If the liver was infected, that relative risk increased to 4.05 (95% CI, 1.45 - 8.71), Nielsen reported.
Viral infections increased the risk by 40% (RR, 1.40; 95% CI, 1.25 - 1.56)."
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