"The dramatic behavioral changes induced by cocaine, such as hyperactivity, are accompanied by post-translational modifications (PTMs) of histones. These modifications result in altered gene expression in the area of the brain known as the nucleus accumbens (NAc), which is associated with pleasure. Past research pointed to the use of histone deacetylase (HDAC) inhibitors as a potential therapy for cocaine addiction. However, there is limited knowledge about both the roles different HDACs have following cocaine use, and how HDAC inhibitors could act to counter those effects. Now, a recent study by Kennedy et al. reveals a mechanism underlying HDAC1 inhibitor-mediated blockade of cocaine-induced molecular and behavioral plasticity via PTMs of histones."
'via Blog this'
'via Blog this'
No comments:
Post a Comment