Mitochondrial components are a possible trigger of auto-inflammatory illnesses

Many illnesses, including psoriasis, include inflammatory responses that occur without an apparent infection and worsen with stress. In a study using cultured human mast cells in vitro and in rats, researchers from Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University identified mitochondrial particles—secreted from live, activated mast cells—as a possible trigger of the inflammation that is common in such illnesses.

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