Neuroinflammation plays a major role in Alzheimer's disease, but whether it represents a cause or a response to pathology is unclear. In the November 27 Nature Reviews Neurology, Dimitrije Krstic and Irene Knuesel argue that age-related chronic inflammation occurs early in the disease and puts neurons under undue stress. The cells respond by accumulating misfolded tau, which in turn derails axonal transport, leading to further neuronal damage, including accumulation of Aβ. They suggest that focusing on this "inflammation hypothesis of AD" could herald new directions in AD research and therapy.
The Alzforum Webinar is on Wednesday, 12 December 2012, at 12:00 noon, U.S. Eastern time, when Knuesel, from the University of Zurich, Switzerland, will explain her concepts. John Breitner, McGill University;Michael Heneka, University of Bonn; Frank Heppner, Charité Universitaetsmedizin Berlin; and Terrence Town, Cedars-Sinai Medical Center, Los Angeles, will join Knuesel for a panel discussion.
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