MECP2 duplication affects immune system as well as brain development

ScienceDaily (Dec. 5, 2012) — In 1999, Dr. Huda Zoghbi and colleagues at Baylor College of Medicine identified the genetic cause of Rett syndrome (a neurological disorder that begins after birth) -- MECP2 mutation. Too little of the MeCP2 protein associated with the gene causes the girls whom it affects to regress, gradually losing their speech, the use of their hands and many cognitive functions. MeCP2 suppressed secretion of gamma interferon from T helper cells, leading to a partial immunodeficiency.