This issue of Neuropsychopharmacology Reviews is focused on epi- (Greek for ‘over’ or ‘above’) genetics, which, in its broadest definition, concerns the regulation of chromatin structure and function (including but not limited to gene expression) in dividing and non-dividing cells. Many epigenetic markings such as DNA methylation, post-translational histone modifications, and histone variants, in concert, define three-dimensional genome architectures inside the nucleus and are thought to serve as a ‘molecular bridge’ by which myriads of external (environmental) and internal factors mold and shape the nascent genetic material throughout the brain and peripheral tissues over the entire lifespan of an organism.
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