Work by Browne, S. K. et al (2012) showed that anti–interferon (IFN)-gamma autoantibodies found in a group of Asian adults with disseminated nontuberculous mycobacterial infection, alone or with another opportunistic infection, had an adult-onset immunodeficiency disease similar in nature to that seen in patients with advanced HIV infection. The cause of the anti-interferon-gamma autoantibodies appeared unrelated to a singular genetic predisposition and the authors speculate that an environmental factor or opportunistic infection could be the trigger.
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