MicrobeWorld - Engineered Gut Bacteria Reverse Type 1 Diabetes in Experimental Mice

Scientists have managed to reverse type 1 diabetes (T1D) in experimental mice by giving the animals an oral course of harmless gut bacteria that had been engineered to secrete the whole proinsulin autoantigen (PINS) and the immunomodulatory human cytokine IL-10 (hIL10). An international team led by scientists at the KU Leuven in Belgium, combined the engineered Lactococcus lactis therapy with a short, low-dose systemic course of the nonspecific immune modulating monoclonal antibody (mAb) anti-CD3.