Futurity.org – Stopping cell and NGF decay may delay Alzheimer’s

Treatment of healthy adult rats with a drug that blocks the maturation of active NGF leads to Alzheimer’s-like losses of cholinergic functional units, which result in cognitive impairment.

A key role for NGF was proposed over 10 years ago in this paper:
 Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice Capsoni S, Ugolini G, Comparini A, Ruberti F, Berardi N, Cattaneo A.Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice.Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6826-31.