Prenatal immune activation interacts with genetic nurr1 deficiency in the development of attentional impairments.

In the present study, we show that the neuropathological consequences of prenatal viral-like immune activation are exacerbated in offspring with genetic predisposition to dopaminergic abnormalities induced by mutations in Nurr1, a transcription factor highly essential for normal dopaminergic development.

Schizophrenia