Research discovers novel mechanism for preventing infection via body's mucosal borders

Researchers  have identified a previously unknown mechanism that generates protective immune memory cells to fight recurring infections at the body's mucosal linings – which include the mouth, the intestines, the lungs and other areas. These are the main entry points for many viruses and other infectious organisms. The findings were published online today in the journal Nature Immunology and open the door to the creation of new and more effective vaccines based on triggering the newly identified mechanism.

Mucosal memory CD8+ T cells are selected in the periphery by an MHC class I molecule

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