Cross-reactive immunity occurs when infection with or vaccination against one virus protects against another related family member. A search for homologues of the HIV-1 envelope glycoprotein revealed that it is composed of thousands of intercalating and overlapping viral matches of pentapeptide or longer gapped consensi, belonging to over 70% of the currently sequenced virome, infecting all kingdoms from bacteria to man. It was also highly homologous to proteins from the Visna/Maedi and other ovine viruses, while other proteins (nef/tat/gag/pol) were homologous to proteins from the equine infectious anaemia virus and HTLV-2/HTLV-3 viruses. This phenomenon suggests that horizontal gene transfer from coinfecting RNA and DNA viruses to retroviruses is extensive, providing a route for the subsequent insertion of non-retroviral genes into human and other genomes via retroviral integration. This homology includes all viruses for which vaccines already exist. Cross-reactive immunity may be operative in AIDS, as Vaccinia vaccination decreases viral replication in HIV-1 infected patients' cells, for the CCR5 tropic form. Measles, Dengue virus, or GB virus C infections also decrease the HIV-1 viral load. A resumption of Vaccinia/smallpox vaccination might be expected to have a significant effect on the AIDS pandemic, and a careful study of the potential uses of other existing viral and bacterial vaccines merits close attention. This phenomenon may also be relevant to other recalcitrant viruses, bacteria, and parasites for which no vaccine exists and the armory of existing vaccines may have a role to play in diseases other than those for which they were designed.
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Concerning the relationships between genes, risk factors and immunity in Alzheimer's disease, Autism, Bipolar disorder , multiple sclerosis, Parkinson's disease, schizophrenia and chronic fatigue
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- ADHD genes and risk factors
- Alzheimer's disease genes and risk factors
- Anorexia Genes and risk factors
- Alzheimer's genes and Herpes simplex
- Autism genes and risk factors
- Bipolar disorder genes and risk factors
- Bornavirus/host interactome
- Borrelia burgdorferi interactome
- Chlamydia pneumoniae interactome
- Helicobacter Pylori host/pathogen interactome
- Herpes simplex host/pathogen interactome
- P.Gingivalis interactome
- T.Gondii: Host/pathogen interactome
- BOOKSTORE
- Childhood Obesity genes and risk factors
- Chronic Fatigue genes and risk factors
- Depression genes and risk factors
- Multiple sclerosis Genes and risk factors
- Parkinson's disease Genes and risk factors
- Pathways in disease (KEGG)
- Schizophrenia Genes and risk factors
- The Microbiome in disease
- Google Scholar
- Cpr/Aed Online Training Certification AHA&ECC Certified
- ACLS Online Certification
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