The NCBI database of HIV-1 virus/ host interactions database records almost 1500 interactions between HIV-1 and human proteins. When mapped out with KEGG pathways it is possible to see the myriad processes affected by the virus during its life cycle. These include many pathways relevant to the associated "side effects" of viral infection including dementia (Alzheimer's pathway) , or psychosis (ERBB signalling or LTP). Numerous immune related pathways are also affected. testifying to the massive effect that the virus has on many aspects of immune function.
Other KEGG pathways
Image via Wikipedia
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