Different strains of
T.Gondii modify host gene expression differently - but all upregulate
VIPR2 a recently characterised important
schizophrenia gene. VIPR2 expression in
macrophages is controlled by Toll receptor
TLR2 or TLR2/6 (
Herrera et al, 2009). T.Gondii binds to galectin 3, an associate of TLR2 , in macrophages
Debierre-Grockiego et al 2010
The
KEGG pathways traced out by schizophrenia genes - now including VIPR2, include several viral and bacterial entry pathways, with
toxoplasmosis heading the list.
Risk factors in schizophrenia including T.Gondii :
Kegg pathways of schizophrenia genes, including toxoplasmosis
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