Microarray gene expression analysis of cells treated with paraquat, a mitochondrial complex 1 inhibitor showed dysregulation of genes involved in neuritogenesis, axon growth and guidance, and synaptogenesis.
Paraquat kills dopaminergic neurones via inhibition of mitochondrial complex 1 of the respiratory chain :
This is also relevant to the recent report citing pesticide use as a risk factor in Alzheimer's disease.
Mitochondria posts
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